Adherence to a healthful plant-based food diet is associated with reduced risk of breast cancer for postmenopausal women, according to a study presented during Nutrition 2022, the annual meeting of the American Society for Nutrition, held virtually from June 14 to 16.
Sanam Shah, M.B.B.S., M.P.H., from Paris-Saclay University, and colleagues examined the association between long-term adherence to a plant-based diet and breast cancer risk among postmenopausal women from the E3N cohort (65,574 women; mean age, 52.8 years) who were followed from 1993 to 2014. Self-reported dietary intake at baseline and during follow-up was used to develop scores for healthful (hPDI) and unhealthful (uPDI) plant-based diets; these were studied as a continuous variable and in quintiles.
The researchers identified 3,968 incident breast cancer cases during a mean follow-up of 21 years. Adherence to hPDI was associated with reduced breast cancer risk (hazard ratio, 0.86 for quintile 5 versus 1). Increased estrogen receptor-positive breast cancer and lobular carcinoma were seen in association with adherence to uPDI (hazard ratio per one standard deviation increase, 1.05 and 1.12, respectively).
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