In Alzheimer’s disease, impaired blood flow to brain regions coincides with tau protein buildup. This relationship strengthens as cognition declines,
Brain regions with impaired blood flow have higher tau levels
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Beta-arrestin-2 increases neurotoxic tau driving frontotemporal dementia
The protein β-arrestin-2 increases the accumulation of neurotoxic tau tangles, a cause several forms of dementia, by interfering with removal